Mutagenic efficiency of organophosphorus insecticides used in combined treatments.
نویسندگان
چکیده
Male mice (Q strain) received two consecutive injections of organophosphorus insecticides: a phosphonate (trichlorfon) was combined to a thiophosphate (methylparathion) or a dithiophosphate (malathion or methylazinphos) in order to evaluate the interactions at the genetic and cytogenetic levels. No increase in chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes. In a dominant lethal mutation assay, the frequency of postimplantation lethality was not significantly increased over the control level. The percentage of preimplantation losses was enhanced, probably due to a toxic effect on male germ cells.
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عنوان ژورنال:
- Environmental Health Perspectives
دوره 60 شماره
صفحات -
تاریخ انتشار 1985